venofer dosing calculator venofer dosing calculator

Avoid or Use Alternate Drug. vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Comparable efficacy to that of IV iron sucrose. Minor/Significance Unknown. Severe adverse reactions including circulatory failure (severe hypotension, shock including in the context of anaphylactic reaction) may occur in pregnant women with parenteral iron products (such as Venofer) which may cause fetal bradycardia, especially during the second and third trimester. 2) Koch TA, Myers J, Goodnough LT. (2015) Intravenous Iron Therapy in Patients with Iron Deficiency Anemia: Dosing Considerations. May increase risk of hypotension. It varies from increases in dietary intake of iron (usually for prophylaxis purposes) to oral, intramuscular or intravenous therapy. Bhowmik D, Modi G, Ray D, Gupta S, Agarwal SK, Tiwari SC, Dash SC. March 2, 2015 [IRON SUCROSE REQUIREMENT CALCULATION FOR SEVERE ANEMIA] DPMU Anantapuramu | National Health Mission 1 Formula for calculating the required dose of Iron sucrose 2.4 X Pre-pregnancy Weight in Kgs X Hb% deficit{11-actual Hb%} in mgs Plus Iron required to replenish the iron stores = 500mg Prepregnancy Weight = 45 kgs . Venofer is manufactured under license from Vifor (International) Inc., Switzerland. IMPORTANT SAFETY INFORMATION DOSAGE AND ADMINISTRATION Pediatric Patients (2 Years of Age and Older) Monitor Closely (1)trientine, iron sucrose. Schweiz Med Wochenschr; 100(7):301-3. For adult CKD patients on ESA therapy who are not receiving iron supplementation, the guideline suggests a trial of IV iron (or in NDD-CKD patients, alternatively, a 1- to 3-month trial of oral iron therapy) if: CKD=chronic kidney disease ESA=erythropoietin-stimulating agent Hb=hemoglobin IV=intravenous RBC=red blood cell WBC=white blood cell. Applies only to oral form of both agents. Found in multiple references. Avoid or Use Alternate Drug. Administer Venofer early during the dialysis session (generally within the first hour). The cost of Venofer is $145 for a dose of 300 mg and Monoferric is $274 for a dose of 500mg. Burns DL, Mascioli EA, Bistrian BR. The dose of Venofer must be individually calculated for each patient according to the total iron deficit calculated with the following Ganzoni formula, for example: Total iron deficit [mg] = BW [kg] x (target Hb - actual Hb) [g/dl] x 2.4* + storage iron [mg] Below 35 kg BW: 35 kg BW and above: Target Hb = 13 g/dl and storage iron = 15 mg/kg BW Monitor Closely (1)aluminum hydroxide will decrease the level or effect of iron sucrose by increasing gastric pH. https://profreg.medscape.com/px/getpracticeprofile.do?method=getProfessionalProfile&urlCache=aHR0cHM6Ly9yZWZlcmVuY2UubWVkc2NhcGUuY29tL2RydWcvdmVub2Zlci1pcm9uLXN1Y3Jvc2UtMzQyMTYy, View explanations for tiers and Feraheme does not contain antimicrobial preservatives. Assessing new treatment options, Intravenous iron-dextran: therapeutic and experimental possibilities. This information is not individual medical advice and does not substitute for the advice of your health care professional. Next Steps Evidence Creator Insights Dr. Andreas M. Ganzoni About the Creator Allow at least 30 minutes between administration of Feraheme and administration of other medications that could potentially cause serious hypersensitivity reactions and/or hypotension, such as chemotherapeutic agents or monoclonal antibodies. Administer Feraheme as an intravenous infusion in 50-200 mL 0.9% Sodium Chloride Injection, USP or 5% Dextrose Injection, USP over at least 15 minutes. In most cases, adult patients require a cumulative dose of elemental iron of at least 1 g. Most commonly, iron replenishment therapy is done intravenously: As total dose (iron-dextran or iron carboxymaltose); Iron deficiency is common during childhood growth, prolonged periods of sickness, in convalescence or during pregnancy. Minor/Significance Unknown. Dosage form: injection, solution Administer Venofer 100 mg undiluted as a slow intravenous injection over 2 to 5 minutes, or as an infusion of 100 mg diluted in a maximum of 100 mL of 0.9% NaCl over a period of at least 15 minutes, per consecutive hemodialysis session. Serious - Use Alternative (1)iron sucrose decreases levels of gemifloxacin by inhibition of GI absorption. Copyright 1993-2021 Official Journal of the International Society of Nephrology. Minor (2)calcium gluconate decreases levels of iron sucrose by inhibition of GI absorption. . Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Applies only to oral form of both agents. and formulary information changes. Avoid or Use Alternate Drug. calcium chloride decreases levels of iron sucrose by inhibition of GI absorption. . There is limited experience with administration of an infusion of 500 mg of Venofer, diluted in a maximum of 250 mL of 0.9% NaCl, over a period of 3.5 to 4 hours on Day 1 and Day 14. Am J Kid Dis 2001; 38 988991. Use alternatives if available. Separate by at least 4 hours. Avoid or Use Alternate Drug. Minor/Significance Unknown. Deferiprone may bind polyvalent cations (eg, iron, aluminum, and zinc), separate administration by at least 4 hr between deferiprone and other medications (eg, antacids), or supplements containing these polyvalent cations. Med J Aust. Minor/Significance Unknown. Available for Android and iOS devices. Applies only to oral form of both agents. Applies only to oral form of both agents. iron sucrose will decrease the level or effect of omadacycline by inhibition of GI absorption. After administration of iron dextran complex, evidence of a therapeutic response can be seen in a few days as an increase in the reticulocyte count. Use Caution/Monitor. Avoid or Use Alternate Drug. Administer Injectafer intravenously, either as an undiluted slow intravenous push or by infusion. Volume of iron product required = 25 mL. Anaphylaxis may occur with IV iron and resuscitation facilities should be available.11 It would appear that iron polymaltose may have a higher incidence of severe systemic reactions than iron sucrose and ferric carboxymaltose. Minor (2)calcium acetate decreases levels of iron sucrose by inhibition of GI absorption. Iron supplements, regardless of their way of administration, are used to replete body stores and to correct anemia. Separate by 2 hr. INFeD is given undiluted at a slow gradual rate not to exceed 50 mg (1 mL) per minute. Applies only to oral form of both agents. This site complies with the HONcode standard for trust- worthy health information: verify here. 1990 Feb;24(2):162-6. For iron maintenance treatment: Administer Venofer at a dose of 0.5 mg/kg, not to exceed 100 mg per dose, every two weeks for 12 weeks given undiluted by slow intravenous injection over 5 minutes or diluted in 0.9% NaCl at a concentration of 1 to 2 mg/mL and administered over 5 to 60 minutes. Minor/Significance Unknown.iron sucrose increases levels of calcium acetate by enhancing GI absorption. Ferrlecit has been administered at sequential dialysis sessions by infusion or by slow intravenous injection during the dialysis session itself. For males: LBW = 50 kg + 2.3 kg for each inch of patients height over 5 feet For females: LBW = 45.5 kg + 2.3 kg for each inch of patients height over 5 feet. Avoid or Use Alternate Drug. Applies only to oral form of both agents. Auerbach M, Witt D, Toler W, Fierstein M, Lerner RG, Ballard H. Clinical use of the total dose intravenous infusion of iron dextran. Intermediate calculations: -Blood volume (dL) = [65 (mL/kg) x body weight (kg)] / 100 (mL/dL) -Hgb deficit (g/dL) = 14.0 - patient hemoglobin conc. Chandler G, Harchowel J, Macdougall I. Applies only to oral form of both agents. Am J Hosp Pharm. Applies only to oral form of both agents. iron sucrose decreases levels of doxycycline by inhibition of GI absorption. Replacement of iron stores found in hemoglobin, myoglobin, and enzymes; works to transport oxygen via hemoglobin, Do not mix with other medications or add to parenteral nutrition solutions for IV infusion, Do not dilute to concentrations below 1 mg/mL, Add dose to 0.9% NaCl infusion bags (PVC or non-PVC); final concentrations range is 1-2 mg of elemental iron/mL, Visually inspect for particulate matter and discoloration prior to infusion, Stable for 7 days at controlled room temperature (25C). In: Koda-Kimble & Young's Applied Therapeutics: The Clinical Use of Drugs. Get in touch with MDApp by using the following contact details: 2017 - 2023 MDApp. Applies only to oral form of both agents. Use Caution/Monitor. iron sucrose decreases levels of deferiprone by enhancing GI absorption. Use Caution/Monitor. Assure stable intravenous access to avoid extravasation. 1000 mg. 20 MINUTES. Human studies not conducted. Iron metabolism needs to be balanced and bleeding, the major cause of iron deficiency (for instance in menstruation in females and chronic occult gastrointestinal bleeding) needs to be addressed. Treatment of anemia due to iron deficiency. Iron supplements, whether administered orally, intramuscular or intravenous, are used to replenish body stores and correct anemia. Use Caution/Monitor. . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. VenAccess is a trademark of Vifor (International) Inc. Switzerland. Both the 200- and 300-mg doses of IV iron sucrose administered over 2 hours appear to be safe. )If you are using this medication at home, learn all preparation and usage instructions from your health care professional. Venofer can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Monitor Closely (1)iron sucrose decreases levels of liothyronine by inhibition of GI absorption. Prior to and at regular intervals during parenteral iron therapy, evaluate serum iron, hemoglobin, and hematocrit. Monitor Closely (1)rabeprazole will decrease the level or effect of iron sucrose by increasing gastric pH. (1970) Intravenous iron-dextran: therapeutic and experimental possibilities. All you have to do is use the following formula: Liquid\ dose = Dose / Medicine\ concentration Liquid dose = Dose/M edicine concentration. Only administer Venofer when personnel and therapies are immediately available for the treatment of serious hypersensitivity reactions. No additional iron to replenish stores. Interaction only with oral iron administration. Dose administration to an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy. Avoid or Use Alternate Drug. Applies only to oral form of both agents. All material on this website is protected by copyright, Copyright 1994-2023 by WebMD LLC. Modify Therapy/Monitor Closely. 3) Bayraktar UD, Bayraktar S. (2010) Treatment of iron deficiency anemia associated with gastrointestinal tract diseases. Either increases effects of the other by pharmacodynamic synergism. This iron deficiency calculator determines the iron deficit based on patient weight, hemoglobin and iron stores to prepare for iron replacement. 4) Gozzard D. (2011) When is high-dose intravenous iron repletion needed? Minor (1)iron sucrose decreases levels of manganese by inhibition of GI absorption. iron sucrose decreases levels of moxifloxacin by inhibition of GI absorption. Avoid or Use Alternate Drug. Interaction only with oral iron administration. It is usually given slowly over 2 to 5 minutes or as directed by your doctor. The two formulas used are presented below: Iron deficit in mg = Weight in kg x (14 Hb in g/dL) x 2.145, Volume of product required in mL = Iron deficit in mg / C in mg/mL. FOR PATIENTS WEIGHING LESS THAN 50 kg: Administer Monoferric as 20 mg/kg actual body weight by intravenous infusion 20 minutes . The plasma ferritin level as a reliable index of body iron stores following intravenous iron dextran. Serious - Use Alternative (1)iron sucrose decreases levels of levofloxacin by inhibition of GI absorption. Use Caution/Monitor. Applies only to oral form of both agents. Applies only to oral form of both agents. Most adults require a cumulative dose of elemental iron of at least 1 g. Iron replenishment is usually doneintravenously, via iron-dextran, iron sucrose or iron carboxymaltose. Modify Therapy/Monitor Closely. Minor/Significance Unknown. Serious - Use Alternative (1)iron sucrose decreases levels of fleroxacin by inhibition of GI absorption. Most Estimates the iron deficit in preparation for iron replacement based on patient weight and haemoglobin. By taking into account the case of a patient weighing 78 kg (172 lbs) and having a hemoglobin level of 11 g/dL (110 g/L or 6.83 mmol/L). Serious - Use Alternative (1)iron sucrose decreases levels of eltrombopag by inhibition of GI absorption. Applies only to oral form of both agents. The recommended Feraheme dose may be readministered to patients with persistent or recurrent iron deficiency anemia. The dose of Ferinject is based on calculation of ideal body weight and calculation of iron deficit using the Ganzoni formula. FERAHEME was non-inferior to Venofer (iron sucrose) in mean Hgb rise from baseline 2,5. For additional Safety Information, please see Full Prescribing Information. Use Caution/Monitor. Serious - Use Alternative (1)iron sucrose will decrease the level or effect of baloxavir marboxil by cation binding in GI tract. ibuprofen/famotidine will decrease the level or effect of iron sucrose by increasing gastric pH. The following table present normal hemoglobin ranges: There is another equation for iron deficit that can be used to calculate replenishment needs, that of Ganzoni, which takes into account iron stores as well and that can be found in the iron deficit calculator. (2010) Diagnosis and management of iron deficiency anaemia: a clinical update. Calculation of total iron deficit for initial repletion: [29] Total cumulative dose (mg) = [Target Hb Actual Hb] weight (kg) 2.4 + [15 weight (kg)] *Hb in g/dl: 2. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Observed Hb = the patients current hemoglobin in g/dl. iron sucrose decreases levels of ibandronate by inhibition of GI absorption. Parenteral iron product is iron sucrose (C = 20 mg elemental iron/mL). Iron deficiency anemia calculator (diagnosis), Iron deficiency anemia vs. Minor/Significance Unknown. The dosage of Venofer is expressed in mg of elemental iron. 1 Dosing for patients who weigh less than 50 kg Fulminant symptoms include confusion, sensation of passing out, paleness. For repletion treatment most patients may require a cumulative dose of 1000 mg of elemental iron administered over 8 dialysis sessions. Use Caution/Monitor. A: Generally acceptable. View the formulary and any restrictions for each plan. Fulminant symptoms may include general paleness, confusion or episodes of passing out. If we don't have the calculator you need we'll try to make it for you and add it to the website. Nutrition. Applies only to oral form of both agents. It should be recognized that iron storage may lag behind the appearance of normal blood morphology. Venofer® (iron sucrose) injection, USP is indicated for the treatment of iron deficiency anemia (IDA) in patients with chronic kidney disease (CKD). Iron deficit - equation derivation: Assumptions: -Blood volume = 65 mL/kg -Hemoglobin conc target =14.0 g/dL -Deficits in body stores are ignored. Applies only to oral form of both agents. Most reactions associated with intravenous iron preparations occur within 30 minutes of the completion of the infusion. IDA symptoms are often nonspecific and include tiredness, weakness, shortness of breath. The usual total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. Applies only to oral form of both agents. Applies only to oral form of both agents. May increase risk of hypotension. Evaluate the hematologic response (hemoglobin, ferritin, iron and transferrin saturation) at least one month following the second Feraheme infusion. The dosage of Venofer is expressed in mg of elemental iron. Applies only to oral form of both agents. iron sucrose decreases levels of ciprofloxacin by inhibition of GI absorption. Initial symptoms may include hypotension, syncope, unresponsiveness, cardiac/cardiorespiratory arrest. The original formula employs the weight in kg but users can input it in lbs and it gets transformed. Venofer treatment may be repeated if necessary. Applies only to oral form of both agents. Copyright 1993-2021 This medicine is sometimes given slowly, and the infusion can take up to 2.5 hours to complete. This website is intended for use by US healthcare professionals only. Venofer may cause clinically significant hypotension. Pasricha SR, Flecknoe-Brown SC, Allen KJ, Gibson PR, McMahon LP, Olynyk JK, Roger SD, Savoia HF, Tampi R, Thomson AR, Wood EM, Robinson KL. Applies only to oral form of both agents. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Monitor Closely (1)iron sucrose decreases levels of levothyroxine by inhibition of GI absorption. You may report side effects to Health Canada at 1-866-234-2345. Each mL contains 20 mg of elemental iron. Monitor Closely (1)vonoprazan will decrease the level or effect of iron sucrose by inhibition of GI absorption. Modify Therapy/Monitor Closely. The factor 2.4 is derived from the following assumptions: a) Blood volume 70 ml/kg of body weight ~7% of body weight b) Iron content of hemoglobin 0.34% Factor 2.4 = 0.0034 x 0.07 x 10000 (conversion for g/dL) Ganzoni AM. Applies only to oral form of both agents. Separate dosing of tetracyclines from these products. Iron Sucrose [ Venofer ] Elemental iron: 20 mg/mL (2.5 mL, 5 mL, 10 mL) Solution, Intravenous [preservative free]: [package insert] INDICATIONS: Venofer is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with chronic kidney disease (CKD). Monitor Closely (1)calcium carbonate will decrease the level or effect of iron sucrose by increasing gastric pH. Minor/Significance Unknown.iron sucrose increases levels of calcium chloride by enhancing GI absorption. Applies only to oral form of both agents. Applies only to oral form of both agents. Injectafer treatment may be repeated if iron deficiency anemia reoccurs. There are three fields in the parenteral iron replacement for iron deficiency anemia calculator: Weight can be input in either lbs or kilograms and the required transformations are performed by the calculator. Many people using this medication do not have serious side effects.Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. Indications: Ferrlecit is an iron replacement product for treatment of iron deficiency anemia in adult patients and in pediatric patients age 6 years and older with chronic kidney disease receiving hemodialysis who are receiving supplemental epoetin therapy.